Understanding the Causes of High Blood Pressure.

Grant number: 628838 | Funding period: 2010 - 2012

Completed

Abstract

High blood pressure causes many life-threatening cardiovascular diseases, including heart failure and stroke. The cause of most high blood pressure is not known. Using an animal model of high blood pressure we have shown that an interaction, in the brain, between the nerve pathways that generate respiratory activity and regulate blood pressure is altered. This occurs early in life and our evidence strongly suggests this may be a cause of high blood pressure.

Related publications (3)

Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

N Marina, APL Abdala, A Korsak, AE Simms, AM Allen, JFR Paton, AV Gourine

2011-09-01

Aims Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia an..

Role of angiotensin in the rostral ventrolateral medulla in the development and maintenance of hypertension

AM Allen

2011-01-01

Whilst crucial for behavioural and homeostatic responses to environmental challenges, chronic elevation of sympathetic nervous sys..

Is augmented central respiratory-sympathetic coupling involved in the generation of hypertension?

AE Simms, JFR Paton, AM Allen, AE Pickering

2010-11-30

Respiratory modulation of autonomic neural activity, with consequent phasic alteration of cardiac and vascular function, has been ..

University of Melbourne Researchers

Andrew Allen